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NOVA - Official Website Cancer Warrior. Cancer Warrior. PBS Airdate: February 2. NARRATOR: Deep in this freezer is a drug of incalculable value. Years in development and millions of dollars spent on research, it is now being tested in human patients. It's an experimental cancer drug called "Endostatin," and if it works, it could profoundly change the way we treat cancer.

Cancer Warrior. Follow Dr. Judah Folkman's extraordinary quest to fight cancer by cutting off blood flow to tumors. Airing February 27, 2001 at 9 pm on PBS. Movies. Lights, camera, action. This collection provides movie reviews, awards season guides, and roundups, plus articles about the history of the industry, how to. BibMe Free Bibliography & Citation Maker - MLA, APA, Chicago, Harvard. Appendix I. A VERY SHORT HISTORY OF PATHOLOGY. Welcome to the introductory Pathology course. Most of you are undergraduate medical students. In this course you will.

John Matt is one of the chosen few selected to test Endostatin at the University of Wisconsin Comprehensive Cancer Center. He is part of what some have called the most anticipated clinical trial in medical history. John gets 1. 2 vials of Endostatin every day. Unlike other cancer drugs, it's not a poison. So far, it's had fewer side effects than aspirin. Endostatin attacks cancer in a way that is so new, so radical, that most experts laughed at the idea when it was first proposed by Dr.

Judah Folkman. Forty years ago he stumbled upon a clue—a hidden secret about how cancer really works. It would become his lifelong quest, to understand this relentless killer and find a better treatment for cancer patients. JUDAH FOLKMAN (Children's Hospital/Harvard Medical School): Patients going through these trials are in a desperate situation. Nothing else has worked and there's little time left and they have a fast clock running. We all have a clock but theirs is very fast. And so they're very scared. JOHN MATT (Endostatin trial participant): I know..

I think my tumor is still growing slightly right now. NARRATOR: John Matt has very advanced cancer.

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He has failed every other therapy he's tried. Endostatin may be his last, best hope. But will it work? NARRATOR: Seven days a week John Matt drives three hours back and forth to the hospital to get his Endostatin infusion.

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Fighting cancer has become his full- time job and it's the toughest battle of his life. JOHN MATT: I know I could die. I should have died a few years ago.

So I already know that I'm living on, as they say, "borrowed time." I want it to work. And we're putting everything we can into making it work. NARRATOR: John is the sixteenth patient in Wisconsin to receive Endostatin. There are many more hoping to be number 1. DUANE GAY (Reporter and Endostatin Trial Participant): Kathy and Jerry, this is more than just a story..

NARRATOR: Duane Gay is a well- known reporter in Milwaukee, Wisconsin. DUANE GAY: It's really the inside story of two family farmers. NARRATOR: In August of 1.

Duane had just received the worst news of his life. DUANE GAY: I was told, "Not only is there extensive cancer in your lungs, numerous tumors, but we've found a large tumor in your liver." Here we were just married one year and planning a long life together and now we're being told that I probably won't be around in six months. NARRATOR: Duane and his wife Teri stopped building the house they had dreamed about for a decade and started on a long, difficult medical odyssey. He had extensive surgery followed by months of chemotherapy.

DUANE GAY: Chemotherapy is a hard thing to partner with because it's a poison. And you walk into the hospital to get your chemotherapy feeling a little bit okay, and you leave feeling worse. NARRATOR: Duane and Teri prayed every morning but the news just got worse. His cancer was still growing and there was nothing more his doctors could do. Eighty miles away, in Madison, Wisconsin, Jim Thomas was inundated with patients trying to get into the Endostatin clinical trial.

JAMES P. THOMAS (University Of Wisconsin Cancer Center): Over 4. The total number of patients is probably going to be in the low twenties, as far as how many patients will actually receive Endostatin here. This is Mr. Gay. He's a 4. NARRATOR: This is how the most important decision in Duane Gay's life will be made. His chances of getting into this study are slim. He has to have the right kind of tumors in places where they can be monitored and easily biopsied.

FRED LEE : Probably the best one would be to biopsy this lesion here. There's some very accessible tumor. JAMES P. THOMAS: This gentleman is certainly an excellent candidate, so I think we'll approach him and ask him about entering into the study. FRED LEE:Sounds great. DUANE GAY: You have a good connection.

NARRATOR: In June of 2. Duane Gay received his first infusion of Endostatin.

From now on, he has to come to the hospital seven days a week. It's a full time commitment. DUANE GAY: For the next couple of months this is my job. And it's a six and a half, seven- hour day on the easy days. But I think it's a small price to pay when you think about it.

I've worked a lot harder at things for less. NARRATOR: This is a Phase One clinical trial and the dose starts out very low. The doctors are mainly looking for side effects, but the patients want Endostatin to stop or shrink their cancer. Watch Repeaters Download Full. JAMES P. THOMAS: Patients that are going into phase one trials, they really are heroic in many aspects.

We really can't advise them about whether something might make them very sick. We have no idea whether it's going to be effective or not.

DUANE GAY:That's good, thanks. I don't want to sound over- dramatic about it, but I'll tell you the way I look at it. It's a war, and this is an enemy that has stolen too many lives and rained misery onto too many families. But I feel honored and humbled to be a soldier and hit that beach. And that's honestly the way that I feel about it right now. NARRATOR: This is Children's Hospital in Boston, an important battlefield in the war against cancer, and where Endostatin was discovered in the laboratory of Dr.

Judah Folkman. It was a hard won discovery—4. C. EVERETT KOOP (Children's Hospital of Philadelphia 1. United States Surgeon General 1.

When the history of medicine is written, it will be a story of a tremendous impact that was, at the beginning, pooh- poohed by his colleagues, at the end, proven to be what he said it would be and to have real, honest- to- goodness, practical value in the lives of patients, which is what Judah started out to do. NARRATOR: Today, treating cancer often involves extreme measures and some of the most poisonous substances known.

DON INGBER (Children's Hospital/Harvard Medical School): Conventional cancer drugs, most of which are still derivatives of, basically, the mustard gases used in warfare in World War I and are really toxic to any cell, have the known side effects of you losing your hair, losing your immune response, affecting your intestinal tract. NARRATOR: Another problem with chemotherapy is drug resistance, which occurs when cancer cells mutate and become resistant to drugs that once worked on them. But Endostatin doesn't attack the cancer cells at all.

It goes after normal cells, the ones that feed the tumor and allow it to grow. Starving cancer by cutting off its food supply was Dr. Folkman's revolutionary idea, which arose almost by accident more than 4. In 1. 96. 1 the U. S. Navy introduced the nuclear- powered aircraft carrier. It was designed to stay at sea for months at a time.

But there was a problem. The blood supply could only be stored for about three weeks. To help find a long- lasting substitute for whole blood the Navy drafted young doctors, among them a surgeon named Judah Folkman. JUDAH FOLKMAN: I was assigned to work on the problem of, "could you dry the hemoglobin part of blood, the red part, like you dry coffee, and then reconstitute it by adding salt water and have it all ready to go?"NARRATOR: Dr. Folkman's job was to find out if reconstituted hemoglobin could keep tissue alive like real blood does.